Drawing from the author's knowledge, experience, and evidence gathered during years of professional activity in Iran, the article offers twenty-two important "lessons learned" concerning the initiation, design, and implementation of ergonomics intervention programs in industries and companies in developing countries, with a focus on Iran. Briefly, a short report of four ergonomics projects implemented in Iran is provided, and then policy suggestions are expressed in the form of lessons. These lessons are derived from the author's practical projects as an ergonomics manager and offer key points to increase the success of ergonomics projects and to expand and sustain ergonomics in industries and companies.